5-MeO-DMT

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5-MeO-DMT is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and at least one toad species, the Sonora Desert toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America

FormulaC13H18N2O
Molar mass218.298 g/mol
ChEMBL Id7257
IUPHAR ID145

Pharmacologies On 5-MeO-DMT

5-MeO-DMT is a methoxylated derivative of DMT. Based on studies in rats, its pharmacological activity is believed to be mainly through serotonin receptors. Specifically, it shows high affinity for the 5-HT2 and 5-HT1A subtypes. Additional mechanisms of action such as inhibition of monoamine reuptake may be involved also. A 2019 European study with 42 volunteers showed that a single inhalation produced sustained enhancement of satisfaction with life, and easing of anxietydepression, and post-traumatic stress disorder (PTSD)

Is 5 MeO DMT the same as DMT?

They’re totally different substances, though 5MeODMT is a chemical derivative of DMT. Firstly, it’s 4 to 6 times stronger than DMT, and has far less of the visuals characteristic of DMT. Instead, 5MeODMT is mostly known for it’s intense perspective shifts and sensory overload

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